La peste se déclare d'abord chez les rongeurs : piqués par des puces infectées, ils meurent rapidement. The Great Plague of London, lasting from 1665 to 1666, was the last major epidemic of the bubonic plague to occur in England. It happened within the centuries-long Second Pandemic , a period of intermittent bubonic plague epidemics that originated in Central Asia in 1331 (the first year of the Black Death ), and included related.